Marcel, Yves


Dr. Yves Marcel was Director of the HDL Biology Laboratory at the University of Ottawa Heart Institute. He was also a cross-appointed Professor in the Department of Pathology and Laboratory Medicine and the Department of Biochemistry, Microbiology and Immunology at the University of Ottawa.


Marcel earned his first degree in Science at the Université de Rouen. In 1961, he obtained a diploma in Chemical Engineering from the Ecole Nationale Supérieure de Chimie de Toulouse and another in Chemistry and Physics from the Université de Toulouse. That year he joined the Faculty of Medicine at the Université de Toulouse as a Biochemistry Assistant.

After completing his Doctorate in Biochemistry in 1965, he worked for two years as a Research Fellow at Hormel Institute at the University of Minnesota. He was then appointed Assistant Professor in the Department of Medicine and Senior Scientist in the Clinical Research Institute at the Université de Montréal. He became Director of the Laboratory of Lipoprotein Metabolism in 1973, serving in this role for 19 years. He also held the position of Professor in the Department of Medicine. Dr. Marcel became Associate Member of the Department of Experimental Medicine at McGill University in Montreal in 1981.

From 1992, Dr. Marcel was Director of the Atherosclerosis, Genetics and Cell Biology Lab, formerly known as the Lipoprotein and Metabolism Laboratory. He also served as Chief Scientific Officer and Vice President of Research for the Heart Institute until 2003.

Yves Marcel was awarded the Royal Society of Canada’s McLaughlin Medal in 1997 and the Ottawa Life Sciences Basic Research Award in 2001.

Research & Clinical Interests 

Yves Marcel’s areas of expertise and interests included HDL, apolipoprotein A-I structure, and reverse cholesterol transport; apolipoprotein E (apoE) association with cell matrix elements of the hepatocyte; and the nature and role of the cell surface apoE in lipoprotein metabolism.


See current publications list at PubMed.

Selected publications:

  • Ouimet M, FranklinV, Mak E, Liao X, Tabas I, Marcel YL. Autophagy Regulates Cholesterol Efflux from Macrophage Foam Cells via Lysosomal Acid Lipase. Cell Metabolism, 2011 13(6):655-67
  • Marcel YL, Ouimet M, Wang M-D. Cellular lipid traffic and lipid transporters: regulation of efflux and HDL formation. In Cellular Lipid Metabolism, C. Ehnholm, Ed. Springer. Pg 73-106, 2009.
  • Marcel YL, Ouimet M, Wang M-D. Regulation of lipid efflux in macrophages. Current Opinion in Lipidology 2008;19(5):455-461.
  • Marcel YL, Ouimet M, Wang M-D. Regulation of cholesterol efflux in macrophages. Curr Opin Lipidol 2008;(19):455-461.
  • Ouimet M, Wang MD, Cadotte N, Ho K, Marcel YL. Epoxycholesterol impairs cholesteryl ester hydrolysis in macrophage foam cells, resulting in decreased cholesterol efflux. Arterioscler Thromb Vasc Biol 2008 Jun;28(6):1144-1150. Epub 2008 Mar 27. PMID: 18369155 [PubMed: indexed for MEDLINE].

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