The Cardiovascular Research Methods Centre collaborates with Heart Institute investigators during all stages of the research process, from protocol design to drafting of a final manuscript for submission to a peer-reviewed journal:
The Centre aims to:
- To collaborate with clinician and basic scientists at all stages of design, development, execution and analysis of experimental protocols.
- To develop unique research methodologies for example in the fields of genetic wide association studies and Randomized Clinical Trials.
- To co-ordinate regular monthly meetings between methodologists and clinical and basic scientists (the goal of these meetings would be to brainstorm ideas, discuss experimental design, review grant applications etc.).
- To develop educational programs in cardiovascular research methodology and statistics (regular courses and workshops at various levels will be offered for clinical and basic scientists as well as other members of staff; these might be mandatory for cardiology residents, first year cardiology fellows and first year basic scientists).
- To develop and maintain research database infrastructure.
- To increase success with grant applications (as part of this aim all grant applications will be reviewed by the centre; further all applications will be provided with a letter of support from the Centre Director which will include a breakdown of budget for methodological support).
The Methods Centre provides these collaborative services to ensure that the latest experimental-design technologies and methods are available to Heart Institute researchers, that the data obtained in research studies are maintained at the highest level of quality and integrity, that the most appropriate and latest statistical analysis techniques are used, and that good clinical practices are allowed.
Teaching Activities
The Centre’s staff provides statistical and epidemiological research training for residents, clinical fellows and fundamental scientists at the Heart Institute. Teaching modules include experimental de3signs, basic and advanced statistical methods, the design and analysis of randomized and non-randomized clinical trials, procedures for systematic reviews and meta-analysis, health technology assessment, economic evaluations and developing and evaluating decision support technologies.
The Centre’s staff can also coordinate training for research personnel in standard operating procedures (SOPs) designed to ensure good clinical practices and good laboratory practices in research study methods and data integrity and analysis.
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Staff
Dr. George A. Wells, Director, Cardiovascular Research Methods Centre
Annie Bai, Research Assistant
Jordan Bernick, Junior Biostatistician
Li Chen, Biostatistician
Jesse Elliott, Research Assistant
Anne Gray, Administrative Assistant
Alomgir Hossain, PhD, Biostatistician
Shu-Ching Hsieh, Research Assistant
Amy Johnston, Research Assistant
Shannon Kelly, Study Coordinator
Wenfei Liu, Research Trainee
Nazmun Nahar, Clerk
My-Linh Tran, Database Manager
Janine Ryan
Patricia Theoret-Patrick
Projects
2005-2010 ACE-Inhibition for the Preservation of Renal Function and Patient Survival in Kidney Transplantation
Principal Investigator: G. Knoll
Co-investigators: D. Fergusson, S. Gourishankar, B. Kiberd, D. Treleaven, M. Karpinski, N. Muirhead, M. Cantarovich, R. Prqasad, J. Gill, P. Hébert, K. McLaughlin, G. A. Wells
Canadian Institutes of Health Research (CIHR)
Funding: $2,946,260 (1st Year $496,763)
2005-2010 Endocrinology of Cardiac Failure and Inflammation
Principal Investigator: A. de Bold
Co-Investigators : M. Kuroski de Bold, H. Haddad, J. Veinot, G. A. Wells, P. Hendry, R. Masters
Canadian Institutes of Health Research (CIHR)
Total amount awarded $553,500 (1st Year $187,640)
2006-2010 Resistance Exercise in Already-active Diabetic Individuals (READI)
Principal Investigator: R. Sigal
Co-Investigators: G. Kenny, L. Donovan, M. Riddell, B. Perkins, S. Hadjiyannakis, G. Goldfield, R. Gougeon, D. Prud’homme, D. Coyle, G. A. Wells, A. Edwards, D. Pacaud, P. Sargious, G. Ford
Canadian Institutes of Health Research (CIHR)
Funding: $1,256,975 (1st Year $306,910)
2007-2010 Tool Development: Improving the Utility of Administrative Databases for Post-Marketing Surveillance of Serious Adverse Events and Health Service Utilization in Patients Receiving Biologic Response Modifying Drugs for Rheumatoid Arthritis
Principal Applicants: C. Bombardier, S. Bernatsky, J. Hux
Co-Applicants: J. Boyle, J. Pope, A. Cividino C. Thorne, G. A. Wells,
G. Tomlinson, M. Paterson
Canadian Institutes of Health Research (CIHR)
Funding: $281,517 (1st Year $41,248)
2007-2010 A Study to Develop Clinical Decision Rules for the Hospital Admission of Patients with Acute Dyspnea
Principal Investigator: I. Stiell
Co-investigators: S. Aaron, B. Rowe, R. Brison, A. Forster, G. A. Wells, J. Perry,
L. Calder
Canadian Institutes of Health Research (CIHR)
Funding: $350,853 (1st Year $158,371)
2007-2010 A program to reduce cardiovascular risk among family members of patients with
Coronary Artery Disease
Principal Investigator: B. Reid, L. Mosca
Co-Investigators: A. Pipe, H. Mochari, G. A. Wells, P. O’Farrell, C. Blanchard, S. Papadakis, M. Slovinec, L. Beaton
Heart and Stroke Foundation of Canada
Funding: $301,029 (1st Year $100,343)
2007-2010 Effectiveness of Dispatch-Assisted CPR Instructions: An Evaluation of 9-1-1
Calls
Principal Investigator: C. Vaillancourt
Co-Investigators: I. Stiell, G. A. Wells
Canadian Institutes of Health Research (CIHR)
Funding: $378,516 (1st Year $185,500)
2007-2011 Phase I: Clinical Decision Rule for High Risk TIA Patients in the ED
Nominated Principal Applicant: J. Perry
Co-Applicants: M. Sharma, M. Emond, I. Stiell, G. A. Wells, M. Sivilotti, A. Worster
Canadian Institutes of Health Research (CIHR)
Funding: $537,844 (1st Year $162,001)
2007-2012 Genome-wide Scan to Identify Coronary Artery Disease Genes
Principal Investigator: R. Roberts
Co-Investigators: A. Stewart, R. McPherson, G. A. Wells
Canadian Institutes of Health Research (CIHR)
Funding $750,000 (1st Year $151,978)
2007-2012 Development of a Canadian Cardiovascular Genetics Centre – the first centre in Canada dedicated to Genetics of Cardiovascular Disease
Principal Investigator: R. Roberts
Co-investigators: M. Andrade, R. Beanlands, M. Gollob, Y. Marcel, R. McPherson, A. Stewart, A. Tang, F. Tesson, G. A. Wells
Canadian Foundation of Innovation ($4,713,346)
Partner Contributions ($7,070,019)
Funding: $11,783,365 (1st Year $2,571,203)
2008-2010 Evaluation of the Safety of C-Spine Clearance by Emergency Department Triage Nurses
(Phase IV)
Principal Applicant: I. Stiell
Co-Applicants: J. Brehaut, B. Davies, J. Grimshaw, A. O’Connor, J. Perry
and G. A. Wells
Canadian Institutes of Health Research (CIHR) – Operating
Funding: $157,354 (1st Year $78,677)
2008-2010 Long-term Effects of Cardiac Resynchronization Therapy on LV Remodeling and Ventricular Arrhythmia: The Reverse Remodeling Study
Nominated Principal Applicant: D. Birnie
Co-Applicants: T. Ruddy, J. Sapp, G. A. Wells
Heart and Stroke Foundation of Ontario
Funding: $98,337 (1st Year $20,100)
2008-2010 A Survey of Factors Associated with the Successful Recognition of Agonal
Breathing and Cardiac Arrest by 9-1-1 Call Takers (Pilot Project Grant)
Principal Applicant: C. Vaillancourt
Co-Applicants: J. Grimshaw, J. Brehaut, I. Stiell, G. A. Wells, M. Osmond
Heart and Stroke Foundation of Ontario (HSFO)
Funding: $49,000 (1st Year $24,921)
2008-2010 Angiotensin Receptor Blocker Post Ablation to Prevent Recurrent Atrial Fibrillation
Principal Applicant: G. A. Wells (Mentor)
Co-investigator: R. Parkash (Mentee)
Canadian Institutes of Health Research (CIHR)
Funding: $20,000 (1st Year $6,666)
2008-2010 Anisnabe Kekendazone: building from the Ottawa ACADRE
Nominated Principal Applicant: N. Andersson, A. Macaulay, G. Sioui
Co-Applicants: J. Arnason, K. Barlow, M. Brklacich, M. Cargo, D. Dannenbaum, M. Dion-Stout, N. Edwards, G. Egeland, S. Findlay, B. Flynn, K. Glass, N. Gibson, K. Gray-Donald, M. Green, P. Haddad, E. Harper, L. Levesque, J. Little, A. O’Connor, O. Receveur, M. Rosenberg, B. Shea, J. Torrie, N. Trocme, P. Tugwell, S. Vollant, G. A. Wells, K. Yeates
Canadian Institutes of Health Research (CIHR)
Funding: $1,493,333 (1st Year $600,000)
2008-2011 Effectiveness and Optimal Use of Biologic Response Modifying Drugs for the Treatment of Rheumatoid Arthritis in Ontario
Principal Investigator: Claire Bombardier, Janet Hux
Co-Applicants: C. Thorne, G. Tomlinson, C. Hofstetter, S. Bernatsky, J. Boyle, V. Bykerk, A. Cividino, A. Lyddiatt, M. Paterson, J. Pope and G. A. Wells
Ministry of Health and Long Term Care
Funding: $700,000 (1st Year $300,000)
2008-2013 CIHR Emerging Team in Genomics in Screening
Nominated Principal Applicant: B. Wilson,
Principal Applicants: Julian Little, June Carroll, Beth Potter, David Castle
Co-Applicants: Judith Allanson, Fiona Miller, Mario Cappelli, Pranesh Chakraborty,
Joe T.R. Clarke, George Wells, Denise Avard, Holly Etchegary, Tim Caulfield, Louise Lemyre & Karine Morin
Canadian Institutes of Health Research (CIHR)
Funding: $1,597,865 (1st Year $300,000)
193 2009-2010 Obstructive Sleep Apnea as a Risk Factor for Clopidogrel Unresponsiveness in Patients
Undergoing Percutaneous Coronary Intervention: Prevalence, Mechanisms and Possible
Influence on Clinical Outcomes
Principal Applicant: D. So
Co-Applicants: G. Chandy, C. Glover, M. Labinaz, M. Le May, J. Leech,
G. A. Wells
Heart and Stroke Foundation of Canada
Funding: $146,200 (1st Year 79,100)
2009-2011 Improving Continuity of Care for Individuals with Chronic Disease
Principal Applicant: A. Cranney
Co-Applicants: G. Alexander, B. De Bruijn, A. Forster, J. Grimshaw, E. Keely,
C. Kendall, J. Martin, I. Stiell, G. A. Wells, J. Worthington
Canadian Institutes of Health Research (CIHR)
Funding : $195,526 (1st Year $97,763)
2009-2010 Using Technology to Create a New Chronic Disease Management Model for Francophone Patients – An Integration Project
Principal Investigator: H. Sherrard
Co-Investigators: L. Duchesne, C. Struthers, G. A. Wells
Socété Santé en Français
Funding: $190,290
2009-2011 Field Validation of an Early Inflammatory Arthritis Screening Tool in the Canadian Primary Health Care Environment
Principal Investigator: M. Bell
Co-Investigators: V. Bykerk, G. A. Wells, P. Tugwell, D. Manca, M. Godwin
Canadian Arthritis Network
Funding: $240,000 (1st Year $120,000)
2009-2011 Remote ECG Monitoring
Principal Investigator: H. Yang
Co-Investigators: T. Ruddy, J. Watters, W. Gofton, P. Jetty, G. A. Wells, A. Chaput
The Ottawa Hospital Academic Medical Organization Innovation Fund
Funding: $606,502 (1st Year $453,372)
2009-2012 BRUISE CONTROL : Bridge oR continUe coumadIn for device SurgEry randomized CONTROLled Trial
Principal Applicants: D. Birnie, V. Essebag
Co-Applicants: A. Krahn, C. Simpson, J. Healey, A. Tang, S. Sivakumaran,
G. A. Wells
Canadian Institutes of Health Research (CIHR) – Randomized Controlled Trial
Funding: $952,839 (1st Year $145,311)
2009-2014 Effect of Folic Acid Supplementation in Pregnancy on Preeclampsia
Principal Applicants: ShiWu Wen, W. Fraser
Nominated Co-Principal Applicant: M. Walker
Co-Applicants: G. Smith, D. Fergusson, G. A. Wells, D. Coyle, A. Ohlsson, S. Davidge
Canadian Institutes of Health Research (CIHR) – Randomized Controlled Trial
Funding: $6,448,423 (1st Year $1,375,734)
2009-2014 Imaging Modalities to Assist with Guiding Therapy and the Evaluation of Patients with Heart Failure (IMAGE-HF)
Principal Applicants: R. Beanlands, J. Knuuti, G. A. Wells, M. Friedrich, G. Wright, J-C. Tardif, S. Yla-Herttuala, M. Arnold,
Co-Applicants: E. Larose, D. Paterson, R. de Kemp, D. Birnie, J. White, G. Wisenberg, B. Chow, D. Coyle, F. Prato, J. Ezekowitz, T-Y. Lee, E. O’Meara
Canadian Institutes of Health Research - Team Grant
Funding: $2,500,000 (1st Year $375,000)
202 2010 Comparison of Chronic Disease Care Delivery Amongst Primary Care Models in Ontario
Principal Applicant: C. Liddy
Co-Applicants: W. Hogg, S. Dahrouge, G. A. Wells
Ministry of Health and Long Term Care, Primary Health Care System (PHCS) Program
Funding: $15,000
203 2010 Planning Meeting for a RCT Grant for the Treatment of AF in Heart Failure Patients
Principal Applicant: A. Tang
Co-Applicants: R. Parkash, M. Talajic, A. Verma, G. A. Wells
Canadian Institutes of Health Research (CIHR) – Planning Grants
Funding: $19,488
2010-2011 Rubidium-82 - An Alternative Radiopharmaceutical for Myocardial Imaging
(RB-ARMI)
Principal Applicants: R. de Kemp, R. Beanlands, G. A. Wells,
Co-Applicants: K. Gulenchyn, J-C. Tardif, G. Wisenberg, P. Pibarot, D. Coyle, E. Turcotte, F. Harel
Canadian Institutes of Health Research (CIHR) - Operating
Funding: $1,121,700 (1st Year $500,000)
2010-2011 Atrial Substrate Modification with Aggressive Blood Pressure Control to Prevent Atrial
Fibrillation
Principal Applicants: R. Parkash, G. A. Wells
Co-applicants: J. Healey, J. Sapp, J-C. Tardif
Canadian Institutes of Health Research - Strategy on Patient Oriented Research Program (SPOR)
Funding: $100,000
2010-2011 The Safety of Biologics for Musculoskeletal Conditions: A Systematic Review and Network Meta-Analysis
Principal Applicant: P. Tugwell, R. Buchbinder, J. Sing, G. A. Wells
Principal Knowledge User: A. Lyddiatt
Co-applicants: R. Christensen, L. Maxwell
Canadian Institutes of Health Research – Knowledge Synthesis Grant
Funding: $53,000
2010-2012 Right Ventricular Substrate Metabolism as a Predictor of Right Heart Failure in Patients with Pulmonary Arterial Hypertension
Principal Investigator: L. Mielniczuk
Co-investigators: R. Beanlands, D. Stewart, G. A. Wells, R. Davies, H. Haddad, R. de Kemp, J. Da Silva, C. Dennie
Heart and Stroke Foundation of Canada – Grant-in-Aid
Funding: $132,938 (1st Year $66,469)
2010-2012 A Study to Derive a Clinical Decision Rule to Predict Short-Term Serious Outcomes in Adult Syncope Patients after Emergency Department Discharge
Principal Co-Applicants: V. Thiruganasambandamoorthy, I. Stiell
Principal Co-Investigator: G. A. Wells
The Physicians Services Incorporated Foundation
Funding: $169,326 (1st Year $84,538.40)
2010-2014 Evaluation of the Safety of C-Spine Clearance by Paramedics
Principal Applicant: C. Vaillancourt
Co-Applicants: I. Stiell, G. A. Wells
Canadian Institutes of Health Research – Operating
Funding: $424,140 (1st Year $99,924)
2010-2014 Ventricular Tachycardia Ablation vs Enhanced Drug Therapy in Structural Heart Disease: The VANISH Trial
Principal Applicants: J. Sapp, A. Tang, G. A. Wells
Co-Investigators: D. Coyle, R. Parkash, W. Stevenson
Canadian Institutes of Health Research (CIHR) – Operating RCT
Funding: $953,998 (1st Year $568,416)
2010-2014 A Study to Prospectively Assess the Safety and Effectiveness of the Ottawa SAH Strategy for the Investigation of Alert Patients Suspected of Having Subarachnoid Hemorrhage (Renewal – Phase III)
Principal Applicant: J. Perry
Co-Applicants C. Hohl, M. Sivilotti, I. Stiell, G. A. Wells, A. Worster
Canadian Institutes of Health Research (CIHR) – Operating
Funding: $1,099,485 (1st Year $204,859)
2011 SR3/1045 What are the Impacts of Preschool Feeding Programmes for Disadvantaged Young Children?
Principal Applicant: E. Kristjansson
Co-Applicants: D. Francis, M. Benkhalti Jandu, S. Liberato, V. Welch, T. Greenhalgh, M. Petticrew, M. Batal, J. Krasevec, M. Arabi, G. A. Wells, E. Noonan, F. Espejo, E. Noonan
The International Initiative for Impact Evaluation (3ie)
Funding: $90,000
2011 Innovative Strategies to Implement Clinical Practice Guidelines for Rheumatoid Arthritis
and Osteoarthritis
Principal Applicant: L. Brosseau, G. A. Wells
Co-applicants: S. Lineker, M. Bell, J. King, L. Casimiro, M. Egan, S. Poitras.
Canadian Institutes of Health Research (CIHR) – Knowledge Translation
Funding: $100,000
2011 Prospective Validation of Soluble Biomarkers as Predictors of Structural Damage in Rheumatoid Arthritis (BIODAM RA) Trial
Principal Applicant: W. Maksymowych, D. van der Heijde, R. Landewé
Co-Applicants: G. A. Wells, J. Bathon, C. Bingham, V. Bykerk, M. Ostergaard, T. Kvein, M. Boers, D. Aletaha, P-P. Tak, O. Fitzgerald, C. Ritchlin, P. Mease, H. El-Gabalawy, W. Lems, D-J. van Schaardenburg, H-B. Hammer, M. Backhaus, B. Combe, G. Ferraccioli for the OMERACT group
Abbott
Funding:
2011-2012 Reassessment of Anti-Platelet Therapy Using Individualized Strategies - Association of Genetic Variants to Adverse Outcomes in Clopidogrel Treated Patients after Percutaneous Coronary Intervention: The RAPID-AGAP study
Principal Applicant: D. So, A. Stewart
Co-Applicants: R. Davies, M. Le May, J. Roberts, G. A. Wells
Canadian Institutes of Health Research (CIHR) - Operating Grant
Funding: $76,244
2011-2013 Risk Stratification of Adult Emergency Department Syncope Patients to Predict Short-Term Serious Adverse Events after Discharge (RiSEDS Study)
Principal Applicant: V. Thiruganasambandamoorthy
Co-applicants: E. Lang, H. Murray, B. Rowe, R. Sheldon, M. Sivilotti, I. Stiell, G. A. Wells
Canadian Institutes of Health Research – Operating Grant
Funding: $352,280 (1st Year $176,140)
2011-2015 Canadian Collaborative for Methods, Applications, and Capacity Development in Network Meta-Analysis for Drug Safety and Effectiveness
Principal Applicant: G. A. Wells, D. Coyle, B. Reeves, H. Schunemann, L. Thabane,
Co-applicants: J. Beyene, C. Cameron, T. Clifford, J. Higgins, S. Klarenbach, K. Lee, Y. Loke, M. Maher, B. Manns, G. Salanti, P. Santaguida, V. Shukla, D. Stacey, S. Sullivan and T. Trikalinos
Canadian Institutes of Health Research (CIHR)
Funding: $911,520 (1st Year $200,241)
2012-2015 Improved Delivery of Cardiovascular Care (IDOCC) through Outreach Facilitation
Principal Applicant: C. Liddy
Co-Applicants: W. Hogg, S. Dahrouge, M. Taljaard, C. Deri Armstrong, G. A. Wells,
G. Russell
Canadian Institutes of Health Research (CIHR)
Funding: $429,302 (1st Year - $143,100)
2011-2015 RAD Study Phase 2: Validation of the Canadian HF and COPD Risk Scores for Respiratory Distress in the Emergency Department
Principal Applicant: I. Stiell
Co-Applicants: J. Perry, S. Aaron, B. Borgundvaag, R. Brison, L. Calder, B. Rowe, A. Forster, G. A. Wells
Canadian Institutes of Health Research (CIHR)
Funding: $852,288 (1st Year - $213,072)
2011-2016 A Randomized Ablation-Based Atrial Fibrillation Rhythm Control Versus Rate Control Trial in Patients with Heart Failure and High Burden Atrial Fibrillation (RAFT-AF)
Principal Applicants: A. Tang, R. Parkash, M. Talajic, A. Verma, G. A. Wells,
Co-Applicants: M. Arnold, D. Birnie, D. Coyle, V. Essebag, J. Healey, L. Macle, G. Newton, J-L. Rouleau, A. Skanes
Canadian Institutes of Health Research (CIHR)
Funding: $4,941,966 (1st Year $988,393)
2012 Catalysis of New Initiatives and Collaborations to Improve Community Bystander
CPR Rates Team Credentials
Principal Applicant: C. Vaillancourt
Co-applicants: J. Grimshaw, J. Brehaut, M. Osmond, I. Stiell, G. A. Wells
Canadian Institutes of Health Research (CIHR) - Knowledge Translation
Funding: $30,000
2012 A Network Meta-Analysis of the Cardio-Cerebrovascular Risk Associated with the Anti-Parkinsonian Combination of Levodopa/Carbidopa/Entacapone
Principal Applicant: G. A. Wells, L. Thabane
Co-applicants: C. Cameron, D. Henry, S. Kelly, Y. Loke, V. Shukla, S. Steiner
Canadian Institutes of Health Research (CIHR)
Funding: $96,329
2012-2013 Syncope Clinic for Identification of Arrhythmias and those at Risk of Death among
Emergency Department Syncope Patients
Principal Applicant: V. Thiruganasambandamoorthy
Co-Applicants: I. Stiell, G. A. Wells, R. Davies
The Ottawa Hospital Academic Medical Organization (TOHAMO)
Funding: $61,465
2012-2013 A Network Meta-Analysis of Atypical Antipsychotics for Schizophrenia
Nominated Principal Applicant: G. A. Wells
Principal Applicant: S. Klarenbach
Co-Applicants: C. Cameron, R. Habib, S. Kelly, K. Lee, V. Shukla
Canadian Institutes of Health Research (CIHR)
Funding: $99,866
2012-2013 A Network Meta-Analysis of Combined Pharmacologic and Behavioural Interventions for Smoking Cessation
Nominated Principal Applicant: G. A. Wells
Principal Applicant: D. Coyle
Co-Applicants: C. Cameron, S. Kelly, Y. Loke, A. Pipe, R. Reid, S. Sullivan
Canadian Institutes of Health Research (CIHR)
Funding: $99,775
2012-2013 Early Disposition of Chest Pain Patients Using the New Troponin Assay to Improve Emergency Department Overcrowding
Principal Investigator: V. Thiruganasambandamoorthy
Co-Investigators: I. Stiell, R. Booth, G.A. Wells, R. Beanlands
The Ottawa Hospital Academic Medical Organization (TOHAMO)
Funding: $99,517
2012-2015 Improving the Cardiac Arrest Diagnostic Accuracy of 9-1-1 Emergency Medical Dispatchers
Principal Investigator: C. Vaillancourt
Co-investigators: L. Calder, I. Stiell, G.A. Wells
Heart and Stroke Foundation of Ontario
Funding: $272,978 (1st Year - $149,984)
2012-2015 A Multicenter Prospective Cohort Study of Adverse Events Among Patients Discharged with Sentinel Cardiovascular Emergency Department Diagnoses
Principal Applicant: L. Calder
Co-applicants: M. Sivilotti, I. Stiell, M. Taljaard, V. Thiruganasambandamoorthy, G. A. Wells
Canadian Institutes of Health Research (CIHR)
Funding: $428,829 (1st Year - $151,140)
2012-2015 Statistical Methods of Estimating Genetic Associations of Low Detectability
Principal Applicant: D. Bickel
Co-applicants: C. Greenwood, J. Little, R. McPherson, A. Stewart, G. A. Wells,
B. Zanke
Canadian Institutes of Health Research (CIHR)
Funding: $280,701 (1st Year - $116,500)
2012-2016 Phase II: Clinical Decision Rule for High Risk TIA Patients in the Ed
Principal Applicant: J. Perry
Co-applicants: M. Emond, C. Hohl, M. Sharma, M. Sivilotti, I. Stiell, G. A. Wells
Canadian Institutes of Health Research (CIHR)
Funding: $1,059,584 (1st Year - $249,983)
2013 Resynchronization/Defibrillation for Ambulatory Heart Failure Trial in Patients with Permanent AF (RAFT-PermAF)
Nominated Principal Applicants: A. Tang,
Principal Applicants: D. Exner, J. Healey, R. Parkash, J-L. Rouleau, M. Talajic, G. A. Wells
Co-Applicants: D. Birnie, D. Coyle, A. Krahn, G. Newton, F. Philippon, D. Redfearn, B. Thibault, R. Yee
Canadian Institutes of Health Research - Operating
Funding: $100,000
2013-2014 Validating a Screening Strategy to Improve the Detection of Adverse Drug Reactions in Emergency Departments
Project Lead: M. Sivilotti
Co-Investigators: C. Hohl, J. Lexchin, J. Perry, J. Singer, G. A. Wells
Canadian Medical Protective Association (CMPA)
Funding: $50,000
2013-2015 CHRS Cardiac Implantable Electrical Device Surveillance System (CDSS) – A Pilot Study
Principal Investigator: R. Parkash
Co-applicants: J. Healey, A. Krahn, D. Exner, R. Yee, C. Simpson, E. Crystal, P. Nery, B. Thibault, E. Stephenson, V. Essebag, F. Philippon, A. Tang , G. A. Wells
Heart and Stroke Foundation of Canada
Funding: $161,201 (1st Year - $97,481)
2013-2015 Reassessment of Anti-Platelet Therapy using InDividualized Strategies – Modifying Acute CoroNary Syndrome Algorithms based on Genetic and Demographic Evaluation: The RAPID-MANAGE Pilot Study
Nominated Principal Applicant: D. So
Principal Applicant: J-F. Tanguay
Co-Applicants: C. Glover, R. McPherson, G.A. Wells,
Canadian Institutes of Health Research - Operating
Funding: $192,620 (1st Year - $96,310)
2013-2015 AMSTAR-NRS: Helping Decision Makers Distinguish High and Low Quality Systematic Reviews of Non-Randomized Studies
Principal Investigator: B. Shea
Co-Investigators: N. Andersson, D. Henry, E. Kristjansson, D. Moher, G. A. Wells
Canadian Institutes of Health Research – Operating
Funding: $148,905 (1st Year - $74,453)
2013-2016 Double Short vs Standard Exposure Duration During Cryoballoon Pulmonary Vein Isolation: The DOSE Study
Principal Investigator: J. Andrade
Co-applicants: A. Tang, G.A. Wells
Heart and Stroke Foundation of Canada – Grant-in-Aid
Funding: $207,911 (1st Year - $96,514)
2013-2016 A Randomized Controlled Comparison of Electrical versus Pharmacological Cardioversion for Emergency Department Patients with Recent-Onset Atrial Fibrillation and Flutter (RAFF)
Principal Investigator: I. Stiell
Co-applicants: R. Brisson, D. Birnie, B. Borgundvaag, J. Perry, G. A. Wells
Heart and Stroke Foundation of Ontario– Grant-in-Aid
Funding: $255,354 (1st Year – $82,903)
2013-2016 Randomized Trial of Nordic Walking vs. Standard Cardiac Rehabilitation in Patients with
Heart Failure
Principal Investigator: R. Reid
Co-Applicants: A. Pipe, G. A. Wells, K. Chan, L. Mielniczuk, H. Tulloch, A. Mark, J. Harris, M-L. Keast
Heart and Stroke Foundation of Canada
Funding: $251,919 (1st Year - $81,912)
2014 Frequent Ventricular Premature Contractions in Heart Failure: Prevalence and Prognosis
Principal Applicants: M. Deyell, A. Tang
Co-Applicants: J. Sapp, G. A. Wells
Canadian Institutes of Health Research - Operating
Funding: $63,008
2014-2015 Pharmacological Treatments for Rheumatoid Arthritis and Inflammatory Bowel Disease: A Network Meta-Analysis
Principal Applicants: G. A. Wells, Y. Loke
Co-Applicants: C. Cameron, L. Chen, S. Kelly, E. MacDonald, A. Rostom, J. Singh,
P. Tugwell
Canadian Institutes of Health Research – Other: Rapid Funding for Drug Safety and Effectiveness Network (DSEN)
Funding: $175,292
2014-2015 New Oral Anticoagulants for the Treatment and Prevention of Venous Thromboembolism: A Systematic Review and Network Meta-Analysis
Principal Applicant: G. A. Wells, B. Reeves
Co-Applicants: C. Cameron, M. Carrier, L. Chen, J. Elliott, S. Kelly, V. Shukla,
S. Steiner
Canadian Institutes of Health Research – Other: Rapid Funding for Drug Safety and Effectiveness Network (DSEN)
Funding: $119,896
2014-2016 BRUISE CONTROL-2: A Randomized Controlled Trial to Compare Continued versus Interrupted Dabigatran at the Time of Device Surgery in Patients at High Risk of Stroke
Principal Investigator: D. Birnie, V. Essebag
Co-Applicants: J. Healey, D. Coyle, J. Sapp, A. Verma, G. A. Wells
Heart and Stroke Foundation of Canada – Grant-in-Aid
Funding: $172,500 (1ST Year - $58,500)
2014-2017 Candrive Prospective Older Driver Study
Nominated Principal Applicant: S. Marshall
Principal Applicants: M. Bédard, I. Gelinas, G. Naglie, M. Porter, H. Tuokko, B. Vrkljan
Co-Applicants: S. Gagnon, L. Li, B. Mazer, A. Myers, M. Rapoport, I. Stiell, G. A. Wells
Canadian Institutes of Health Research (CIHR) - Operating
Funding: $1,386,733 (1st Year - $897,656)
2014-2017 Improving Randomized Controlled Trials for Equity-Oriented Decisions
Nominated Principal Applicants: V. Welch
Principal Applicant: P. Tugwell
Knowledge User: H. White
Co-Applicants: G. Grimshaw, E. Kristjansson, D. Moher, T. Pantoja, M. Petticrew, K. Pottie, B. Shea, G. A. Wells
Canadian Institutes of Health Research (CIHR) - Operating
Funding: $220,442 (1st Year - $72,062)
2014-2017 The Effect of Statin Therapy on CFR and Markers of Inflammation in HIV Positive
Individuals
Principal Applicants: P. MacPherson, G. Dwivedi
Co-Applicants: R. Beanlands, J. Angel, K. Chan, R. deKemp, G. A. Wells,
V. Corrales-Medina, C. Tremblay
The Ontario HIV Treatment Network (OHTN) - Operating
Funding: $374,252
2014-2017 Cardiovascular Biomarker Translation (CBT) Program
Academic Project Leader: P. Liu, Gabriela Bucklar-Suchankova
User Organization Project Leader: C. Zaugg
Methodology Expert: G. A. Wells
Project Team Members: U. Wienhues-Thelen, M. Felker, A. Ziegler, L. Mielniczuk
Genome Canada - $1,953,663; Roche - $2,584,345;
University of Ottawa Heart Institute - $1,366,654
Funding: $5,904,662
2014-2019 Resynchronization/Defibrillation for Ambulatory Heart Failure Trial in Patients with Permanent AF (RAFT-PermAF)
Nominated Principal Applicant: A. Tang
Principal Applicant: D. Exner, J. Healey, R. Parkash, M. Talajic, G. A. Wells
Co-Applicants: D. Birnie, D. Coyle, V. Essebag, A. Krahn, G. Newton, F. Philippon, D. Redfearn, B. Thibault, Yee, R.,
Canadian Institutes of Health Research (CIHR) - Operating
Funding: $3,265,595 (1st Year - $633,094)
2014-2019 Methods and Applications Group for Indirect Comparisons
Principal Applicant: S. Straus, A. Tricco, B. Hutton, D. Moher, G. A. Wells
Co-Applicants: B. Hemmelgarn, S. Majumdar, D. Stacey, D. Coyle, et al
Canadian Institutes of Health Research – Drug Safety and Effectiveness Network (DSEN) collaborating Centre for Network Meta-Analysis
Funding: $6,998,765 (1st Year - $816,523)
2014-2019 Canadian Arrhythmia Network (CANet) - Network of Centre of Excellence (NCE)
Principal Applicants: A. Tang (Nominated), G. A. Wells, B. Sheldon
Natural Sciences and Engineering Research Council of Canada (NSERC) $14,374,000
Social Sciences and Humanities Research Council (SSHRC) $2,951,000
Canadian Institutes of Health Research (CIHR) $8,937,024)
Funding: $26,262,024
250 2015 Antimicrobial Resistance (AMR)
Principal Investigator: G. A. Wells
` Co-Investigators: S. Kelly, D. Beking, V. Shukla
World Health Organization (WHO) - Contract
Funding: $16,660 (1st Year - $14,000 US)
2015-2016 The Safety and Efficacy of Femoral Access Versus Radial Access for Primary PCI in
STEMI (The SAFARI-STEMI Trial)
Principal Applicants: M. Le May, G. A. Wells
Co-Applicants: D. Coyle, A. Quraishi
Canadian institutes of Health Research (CIHR) – Transitional Operating
Funding: $100,000
2015-2016 Neurocognitive Outcomes after Out-of-Hospital Cardiac Arrest
Principal Applicants: H. Tulloch, B. Collins, A. Smith
Co-Applicants: M. Le May, G.A. Wells
Canadian Institutes of Health Research – Transitional Operating
Funding: $100,000
2015-2016 Neurocognitive Outcomes after Out-of-Hospital Cardiac Arrest
Principal Investigator: H. Tulloch, B. Collins
Co-Applicant: T. McHugh, M. Le May, L. Duchesne, B. Quinian,
A-S. Nesrine, G.A. Wells
Heart and Stroke Foundation of Canada – Grant-in-Aid
Funding: $149,644 (1st Year – $52,090)
2015-2016 Cardiac Sarcoidosis Multicenter Prospective Cohort
Principal Applicants: D. Birnie (Nominated), R. Beanlands, P. Nery
Co-Applicants: S. Aaron, S. Chakrabarti, R. De Kemp, V. Essebag, M. Friedrich,
L. Gula, A. Ha, J. Healey, T. Hruczkowski, P. Liu, R. Quinn, L. Rivard, J. Sapp, A. Tang,
G. A. Wells, G. Wisenberg
Canadian Institutes of Health Research (CIHR) – Transitional Operating
Funding: $100,000
2015-2018 Myocardial Blood Flow Reserve and Vascular Inflammation in Psoriasis & Psoriatic
Arthritis: Response to Biologics
Principal Applicant: G. Dwivedi
Co-Applicants: R. Beanlands, B. Chow, R. De Kemp, S. Glassman, J. Karsh,
G. A. Wells
Canadian Institutes of Health Research (CIHR) – Operating
Funding: $315,576 (1st Year - $105,192)
2015-2018 Reassessment of Anti-Platelet Therapy using InDividualized Strategies – Ticagrelor in
Patients with Acute Coronary Syndromes Treated by Coronary Artery Bypass Graft
Surgery – A Pharmacodynamic and Clinical Study to Decrease Bleeding Risks and
Ischemic Complications – The RAPID-TITRATE CABG Study.
Principal Applicant: D. So, F. Rubens, J-F. Tanguay
Co-Applicants: V. Chan, A. Chong, J. Dupuis, B. Hibbert, M. Lordkipanidzé,
L. Perrault, M. Ruel, G. A. Wells
Canadian Institutes of Health Research (CIHR) – Operating
Funding: $512,179 (1st Year - $170,726