Energy Substrate Metabolism Research Laboratory

Our research goals are to understand:

  1. The physiological importance of local DPP4 activity and substrate cleavage in the setting of diabetes and cardiovascular disease.
  2.  The cellular sites of DPP4 important for regulation of glucose and lipid metabolism.
  3. How the gut adapts to food ingestion.
Publications 

See current publications list at PubMed.

Selected publications:

  • Morrow NM, Locatelli CAA, Hanson AA, Imran S, and Mulvihill EE. (2022). Adaptation to Short-term Extreme Fat Consumption Alters Intestinal Lipid Handling in Male and Female mice. BBA - Molecular and Cell Biology of Lipids. 

  • dos Santos T, Galipeau M, Schukarucha Gomes A, Lee D, Maghera J, Perera I, Polischevska K, Shayeganpour K, van Allen K, Wang Y, Greenberg M, Larsen M, Mulchandani C, Patton M, Ramdass S, Vafaeian K, Weisz T, Estall JL, Mulvihill EE, Screaton RA. (2022) Islet Biology Advances during COVID-19: Progress and Perspectives. Canadian Journal of Diabetes

  • Morrow NM, Trzaskalski NA, Hanson, AA, Fadzeyeva E, Telford DE, Choker S, Sutherland BG, Edwards JY, Huff MW, Mulvihill EE. (2022). Nobiletin Prevents High-fat diet induced Dysregulation of Intestinal Lipid Metabolism and Attenuates Post-prandial Lipemia. Arteriosclerosis, Thrombosis, and Vascular Biology. 42(2): 127-144.
    Ussher JRU, Greenwell A, Nguyen MA, Mulvihill EE. (2022). Cardiovascular Actions of Incretin Based Therapies: Integrating Mechanisms with Cardiovascular Outcomes Trials. Diabetes. 71(2): 173-183.

  • Dann MM, Clark SQ, Trzaskalski NA, Earl CC, Schepers LE, Pulente SM, Lennord EN, Annamalai K, Gruber JM, Cox AD, Lorenzen-Schmidt I, Seymour R, Kim KH, Goergen CJ, Mulvihill EE. (2022) Quantification of Murine Myocardial Infarct Size using 2D and 4D Ultra-High Frequency Ultrasound. American Journal of Physiology - Heart and Circulatory P.hysiology. 322(3): H359-H372.

  • Varin EM*, Mulvihill EE*, Baggio LL, Koehler J, Cao X, Seeley R, Drucker DJ. Distinct neural sites of GLP-1R expression mediate physiological vs. pharmacological control of incretin action. Cell Reports. 2019; 27: 3371–3384. (*Authors contributed equally).

  • Varin EM*, Mulvihill EE*, Beaudry JL, Pujadas G, Fuchs S, Tanti Fazio JF, Kaur K, Matthews D, Baggio LL, Campbell JE, Drucker DJ. Hepatocyte-derived dipeptidyl peptidase 4 controls obesity-associated inflammation but not glucose homeostasis. Cell Metabolism. 2019; 29: 320-334. (*Authors contributed equally).

  • Ussher JR, Campbell JE, Mulvihill EE, Baggio LL, Bates HE, Gopal K, Lamont BJ, Ilkayeva O, Ali S, Kim M, Kabir MG, Seino Y, Newgard CB, Suzuki J, Drucker DJ. Inactivation of the Glucose-Dependent Insulinotropic Peptide Receptor Improves Outcomes Following Experimental Myocardial Infarction. Cell Metabolism. 2018; 2: 450-460.

  • Mulvihill EE*, Varin EM*, Gladanac B, Campbell JE, Ussher JR, Baggio LL, Ayala J, Burmeister M, Yusta B, Holland D, Bang AKW,, Casper R, Ayala JE, Drucker DJ. Cellular ablation of Dpp4 reveals mechanism of glucose control. Cell Metabolism. 2017; 25(1): 152-165. (*Authours contributed equally).

Positions Available 
Dr. Mulvihill’s laboratory is currently accepting applications. Please send your CV and a letter outlining your interests to emulvihill@ottawaheart.ca