Essais cliniques

Sans recherche, pas de nouveaux traitements! Or, l’Institut de cardiologie de l’Université d’Ottawa (ICUO) est à cet égard un terrain d’autant plus fertile que sa recherche, si elle s’amorce et s’achève comme toute autre dans un laboratoire, a la particularité de se poursuivre et de se compléter au chevet des patients.

Jusqu’à 200 essais cliniques se déroulent à tout moment à l’ICUO à différentes étapes des études en cours. Nous sommes parfois à l’origine de ces études et les seuls à les mener. Nous collaborons aussi avec d’autres établissements à de vastes recherches d’envergure nationale ou internationale, qu’il nous arrive de diriger. Chaque année, des milliers de volontaires, pour la plupart des patients, mais aussi des personnes en bonne santé, participent à nos études. À l’heure actuelle, 50 scientifiques et chercheurs cliniques mènent des essais cliniques dans nos locaux.

Pour plus d’informations, contactez JoinAStudy@ottawaheart.ca

Essais cliniques à l’Institut de cardiologie de l’Université d’Ottawa (en anglais seulement)

Statut Study
Recruiting Patient Engagement Study to Evaluate the Use of Biological Therapies for Cardiac Arrhythmias
Recruiting Transcatheter Mitral Valve Repair for Inotrope Dependent Cardiogenic Shock
  • Conditions: Cardiogenic Shock,   Mitral Regurgitation
Recruiting CAPITAL DOREMI 2: Inotrope Versus Placebo Therapy for Cardiogenic Shock
Recruiting An Evaluation of the Talk Test for Exercise Prescription for Home-Based Cardiac Rehabilitation
Recruiting AERIAL Trial: Antiplatelet Therapy in Heart Transplantation
  • Conditions: Cardiac Allograft Vasculopathy,   Heart Transplant
  • Sponsor: Ottawa Heart Institute Research Corporation,   Canadian Institutes of Health Research (CIHR)
Recruiting Acute Responses to Exercise in Females and Males With Symptomatic Atrial Fibrillation
  • Conditions: Atrial Fibrillation,   Persistent Atrial Fibrillation
Recruiting Improving Goal Directed Medical Therapy for Device Clinic Patients With Reduced EF at UOHI: a QI Initiative (VIGILANT)
  • Interventions: 
  • Sponsor: Ottawa Heart Institute Research Corporation,   Novartis,   Servier,   AstraZeneca
Recruiting A Randomized Trial of Lenient Versus Strict Arm Instruction Post Cardiac Device Surgery
Recruiting REvascularization and Valve Intervention for Ischemic Valve diseasE: REVIVE Trial
  • Conditions: Mitral Valve Insufficiency,   Coronary Artery Disease
Recruiting Watchman for Patients With Atrial Fibrillation Undergoing Transcatheter Mitral Valve Repair (WATCH-TMVR)
  • Conditions: Nonvalvular Atrial Fibrillation,   Severe Degenerative Mitral Regurgitation
  • Interventions: Procedure MitraClip TMVR and Watchman LAAO
Recruiting Bentracimab (PB2452) in Ticagrelor-treated Patients With Uncontrolled Major or Life-Threatening Bleeding or Requiring Urgent Surgery or Invasive Procedure
  • Conditions: Hemorrhage,   Urgent Surgery,   Invasive Procedure
  • Interventions: Drug Bentracimab (PB2452) Infusion
Recruiting Exercise Training in Women With Heart Disease
  • Conditions: Cardiovascular Diseases,   Coronary Heart Disease
  • Interventions: Behavioral Exercise
Recruiting Amplatzer Amulet LAAO vs. NOAC
  • Conditions: Atrial Fibrillation,   Stroke,   Bleeding
Recruiting Surgical PA-LAA Shunting: a Feasibility Study
  • Interventions: Procedure PA-LAA shunt
Recruiting MitraClip REPAIR MR Study
Recruiting Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation
  • Conditions: Mitral Regurgitation,   Mitral Insufficiency,   Mitral Valve Insufficiency,   Cardiovascular Diseases,   Valve Disease, Heart,   Heart Valve Diseases,   Functional Mitral Regurgitation,   Degenerative Mitral Valve Disease
Recruiting The COVID-RASi Trial (COVID-19)
  • Conditions: COVID-19,   Cardiovascular Diseases
Recruiting Barrier-Protect Study
  • Interventions: Other Barrier dressing
Recruiting Evaluating Auscul-X, a Touch Free Digital Stethoscope
  • Interventions: Device Auscul-X
  • Sponsor: AusculSciences Canada Inc.,   Ottawa Heart Institute Research Corporation
Recruiting A Study of ARRY-371797 (PF-07265803) in Patients With Symptomatic Dilated Cardiomyopathy Due to a Lamin A/C Gene Mutation
  • Conditions: Dilated Cardiomyopathy,   Lamin A/C Gene Mutation
Recruiting Randomization of Single vs Multiple Arterial Grafts
  • Conditions: Coronary Artery Disease,   Heart Diseases
  • Sponsor: Weill Medical College of Cornell University,   National Heart, Lung, and Blood Institute (NHLBI),   Canadian Institutes of Health Research (CIHR)
Recruiting Cytisine Compared to Combination NRT in Relapsed Smokers
  • Conditions: Smoking Cessation,   Coronary Artery Disease
Recruiting Multi-Center Evaluation of Feasibility of SPECT Measurement of Myocardial Blood Flow and Reserve
  • Interventions: 
  • Sponsor: Ottawa Heart Institute Research Corporation,   GE Healthcare
Recruiting Outcome Study Assessing a 75 Milligrams (mg) Dose of Macitentan in Patients With Pulmonary Arterial Hypertension
Recruiting Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG
  • Conditions: Atrial Fibrillation,   Stroke,   Bleeding
  • Sponsor: Icahn School of Medicine at Mount Sinai,   National Heart, Lung, and Blood Institute (NHLBI),   Vanderbilt University Medical Center
Recruiting Study to Investigate CSL112 in Subjects With Acute Coronary Syndrome
Recruiting TRILUMINATE Pivotal Trial
  • Interventions: Device Tricuspid valve repair
Recruiting Sildenafil for the Prevention of Right Heart Failure Following LVAD Implantation
  • Interventions: Drug Sildenafil Citrate
  • Sponsor: University of Calgary,   Pfizer
Recruiting Treatment in Thoracic Aortic Aneurysm: Surgery vs Surveillance
  • Conditions: Ascending Aortic Aneurysm Enlargement,   Ascending Aorta Aneurysm
  • Interventions: Procedure Thoracic Aortic Surgery
  • Sponsor: Ottawa Heart Institute Research Corporation,   University of Calgary
Recruiting HEARTBiT: Multi-Marker Blood Test for Acute Cardiac Transplant Rejection
  • Conditions: Heart Transplant Failure and Rejection,   Heart Failure,   Heart Diseases,   Heart Failure，Congestive,   Transplant, Failure, Heart,   Transplant Failure
  • Interventions: 
  • Sponsor: University of British Columbia,   Canadian Institutes of Health Research (CIHR),   PROOF Centre of Excellence,   Duke University,   University of Nebraska,   Toronto General Hospital,   St. Paul's Hospital, Canada
Recruiting Smartphone Assessment Prior Radial Artery Harvesting for CABG
Recruiting Canadian Study of Arterial Inflammation in Patients With Diabetes and Vascular Events: EvaluatioN of Colchicine
  • Conditions: Cardiovascular Diseases,   Atherosclerosis,   Inflammation,   Diabetes
  • Sponsor: Ottawa Heart Institute Research Corporation,   Canadian Institutes of Health Research (CIHR)
Recruiting The Effect of High-Intensity Interval Training on Glucose Variability and Atrial Fibrillation Symptoms
  • Conditions: Atrial Fibrillation,   Type 2 Diabetes
  • Interventions: Behavioral High-intensity interval training + standard care
Recruiting Healing Hearts Together: Evaluating a Couples-based Intervention to Improve Health Outcomes
  • Interventions: Other Healing Hearts Together
Recruiting Left Atrial Imaging Prior to Cardioversion: Leveraging Computed Tomography to Rule Out Thrombus
Recruiting Effect of a Hybrid Rehabilitation Program on Walking, Quality of Life & Cardiovascular Risk in People With PAD
  • Interventions: Behavioral HY-PAD
  • Sponsor: Ottawa Heart Institute Research Corporation,   AFP Innovation Fund
Recruiting Exercise Training in Patients With Persistent or Permanent Atrial Fibrillation (Exercise-AF)
  • Conditions:Persistent or Permanent Atrial Fibrillation (Exercise-AF)
  • Interventions:Participants will attend on-site moderate-intensity continuous exercise training two times weekly for 12 weeks. Participants will attend on-site high-intensity interval training two times weekly for 12 weeks.
Recruiting Rivaroxaban Post-Transradial Access for the Prevention of Radial Artery Occlusion
  • Interventions: Drug Rivaroxaban 15 MG Oral Tablet [Xarelto]
Recruiting Cardiac Sarcoidosis Randomized Trial
  • Conditions: Cardiac Sarcoidosis,   Sarcoidosis
  • Sponsor: Ottawa Heart Institute Research Corporation,   Canadian Institutes of Health Research (CIHR)
Recruiting The Minimally Invasive Coronary Surgery Compared to STernotomy Coronary Artery Bypass Grafting Trial
  • Sponsor: Ottawa Heart Institute Research Corporation,   London Health Sciences Centre,   Heart Center Leipzig - University Hospital,   Fortis Escorts Heart Institute,   The Methodist Hospital Research Institute,   Carolinas Medical Center,   Gundersen Lutheran Health System,   Jilin Heart Hospital,   Far Eastern Memorial Hospital,   Medtronic,   Apollo Hospitals Enterprise Limited,   Fresno Heart and Surgical Hospital,   Ichinomiya-Nishi Hospital
Recruiting Peer Support for Women With Heart Disease: Women@Heart
  • Conditions: Coronary Heart Disease,   Women's Health
  • Interventions: Behavioral Women@Heart Program
Recruiting Exercise Training in Patients With Persistent or Permanent Atrial Fibrillation
Recruiting Characterization of Arrhythmia Substrate to Ablate Persistent Atrial Fibrillation
  • Interventions: Procedure Catheter ablation
  • Sponsor: Ottawa Heart Institute Research Corporation,   Heart and Stroke Foundation of Canada
Recruiting Spironolactone Therapy in Chronic Stable Right HF Trial
  • Conditions: Chronic Right-Sided Heart Failure,   Pulmonary Arterial Hypertension,   Pulmonary Hypertension, Primary, 2,   Pulmonary Hypertension, Primary, 3,   Pulmonary Hypertension, Primary, 4,   Cardiomyopathy Right Ventricular
Recruiting Biomarker Guided Discharge of Heart Failure Patients
  • Interventions: Other Biomarker guided discharge algorithm
  • Sponsor: Peter Liu,   Genome Canada,   Roche Diagnostics,   Ottawa Heart Institute Research Corporation
Recruiting Sub-Clinical Atrial Fibrillation Biomarker Study
  • Interventions: 
  • Sponsor: Ottawa Heart Institute Research Corporation,   Population Health Research Institute,   Genome Canada,   Bristol-Myers Squibb,   Pfizer,   Medtronic,   Canadian Institutes of Health Research (CIHR)
Recruiting Study of Angiogenic Cell Therapy for Progressive Pulmonary Hypertension: Intervention With Repeat Dosing of eNOS-enhanced EPCs
  • Sponsor: Northern Therapeutics,   Ottawa Hospital Research Institute
Recruiting Personalized Dosing of Nicotine Replacement (NRT to Effect)
  • Conditions: Tobacco Use Disorder,   Nicotine Dependence
  • Sponsor: Centre for Addiction and Mental Health,   Canadian Cancer Society (CCS),   Ottawa Heart Institute Research Corporation
Recruiting Comparing Hypothermic Temperatures During Hemiarch Surgery
  • Interventions: Procedure Hypothermic circulatory arrest
Recruiting Coronary Physiology and Its Relationship to Anatomy in Patients With Diabetes Mellitus
  • Conditions: Diabetes Mellitus,   Coronary Artery Disease
  • Interventions: Device Pressure Wire Certus, St. Jude Medical, USA
Recruiting Mobilization of Endothelial Progenitor Cells and Aspirin
  • Interventions: Drug Aspirin
Recruiting Circulating BDNF in Patients With Atrial Fibrillation Undergoing Catheter Ablation or Exercise Training
Recruiting Cadmium-zinc-telluride (CZT) Imaging of Myocardial Blood Flow (MBF) (SPECT MBF)
  • Interventions: Other single photon emission computed tomography
  • Sponsor: Ottawa Heart Institute Research Corporation,   GE Healthcare
Recruiting Cardiac FDG PET Viability Registry
  • Conditions: Heart Failure,   Ischemic Heart Disease,   Myocardial Dysfunction
  • Interventions: 
  • Sponsor: Ottawa Heart Institute Research Corporation,   Ontario Ministry of Health and Long Term Care
Recruiting Cardiac Sarcoidosis Multi-Center Prospective Cohort
  • Interventions: 
  • Sponsor: Ottawa Heart Institute Research Corporation,   Ontario Ministry of Health and Long Term Care,   Canadian Institutes of Health Research (CIHR)
Recruiting Multicenter Prospective Study of Low-Flow Low-Gradient Aortic Stenosis (TOPAS Study)
  • Sponsor: Laval University,   University Hospital, Brest
Recruiting Resynchronization/Defibrillation for Ambulatory Heart Failure Trial in Patients With Permanent Atrial Fibrillation
  • Conditions: Heart Disease,   Congestive Heart Failure,   Atrial Fibrillation
  • Sponsor: Ottawa Heart Institute Research Corporation,   Canadian Institutes of Health Research (CIHR)
Recruiting PERIGON Pivotal Trial
  • Interventions: Device Model 400 aortic valve bioprosthesis
  • Sponsor: Medtronic Cardiac Surgery,   Medtronic
Recruiting ASV Effects on Myocardial Energetics and Sympathetic Nerve Function in Heart Failure and Sleep Apnea.
  • Conditions: Heart Failure,   Obstructive Sleep Apnea,   Central Sleep Apnea
  • Interventions: Other [C11]Acetate and HED PET
Recruiting Optimal Anticoagulation for Higher Risk Patients Post-Catheter Ablation for Atrial Fibrillation Trial
  • Conditions: Atrial Fibrillation,   Stroke
  • Sponsor: Ottawa Heart Institute Research Corporation,   Canadian Institutes of Health Research (CIHR),   Bayer,   Biotronik Canada Inc

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