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At the big-picture level, we understand the risk factors for a heart attack, including high cholesterol, high blood pressure, diabetes, smoking, and genetics. We also know that a heart attack is caused when plaque buildup in the wall of a coronary artery ruptures and blocks the blood vessel. What

Researcher Thomas Lagace, PhD, first came across the protein PCSK9 as a postdoctoral fellow, never guessing that it would become the focus of his career. While starting his post-doc at University of Texas Southwestern Medical Center, he was placed “kind of kicking and screaming,” as he put it, on a

The good news is that their hearts are in the right place. Women in Canada see themselves as their families’ “heart keepers,” playing a significant role in maintaining everyone’s heart health, whether it’s the food they serve, the physical activity they encourage, or the non-smoking households they

[Editor’s note: This article is an update of a previously published story.] Heart disease is the leading cause of death for women worldwide, yet it remains under-diagnosed and symptoms often go unrecognized. In July of this year, the Canadian Women’s Heart Health Centre published the results of a

[Editor’s note: This article is an update of previously published story.] Nearly one in every 100 babies is born with some form of congenital heart disease (CHD). In the 1950s, only about 15% of these children with severe heart defects reached their 18th birthday. Today, with advances in treatment

Finding a gene associated with disease is one thing. Understanding how it increases the likelihood of contracting that disease can be quite another, especially a complex condition like heart disease. After five years, Heart Institute researchers now know how one genetic variant works and suspect

The second annual Ottawa Heart Research Conference convened on May 8, bringing together an enthusiastic community of scientists and trainees to share insights on personalized cardiovascular medicine. The theme was chosen in honour of former University of Ottawa Heart Institute President and CEO

The past decade has seen rapid progress in cataloguing the genetic factors driving heart disease risk. The University of Ottawa Heart Institute led the way, discovering the first and, to date, highest-impact common genetic variant linked to coronary artery disease. Many others have been found since

Since their first appearance in the late 1980s, the cholesterol-lowering drugs known as statins have become one of the most widely prescribed classes of drugs ever produced. The medication is used to treat coronary artery disease (atherosclerosis) by lowering the amount of LDL cholesterol—the “bad”

Lana Gillard was used to going to the University of Ottawa Heart Institute. Her mother was a long-time patient there, suffering from chronic heart failure after many years of treatment and several open-heart surgeries. Gillard accompanied her to appointments and knew her mother was in excellent