Environment versus genetics. Integrating clinical and multiple omics data to understand the causes of diseases; discoveries from this stage can then be used in personalized medicine research for prevention or therapeutic purposes (Figure Source; PMID: 28476144, Copyright: CC BY 4.0).
The Omics and Biomedical Analysis Core Facility, part of The John and Jennifer Ruddy Canadian Cardiovascular Genetics Centre, provides omics, biomedical, genetics and bioinformatics expertise to researchers throughout the University of Ottawa Heart Institute, the Ottawa region and to external researchers internationally.
Focus
A major focus of the core has been large-scale genome-wide association studies (GWAS) to identify genes associated with common cardiovascular diseases and risk factors, including coronary artery disease, hypertension, and obesity.
Services
General
- advice on study design
- sample size and power calculations
- statistical analysis of big data
- genome-wide or high–throughput studies
- compile and interpret results
- manuscript drafting
Genetic Analysis
- genome-wide association analysis
- quantitative genetics
- Mendelian randomization studies
- family-based design
- case-control design
- genomics and personalized-medicine research
Bioinformatic Analysis
- multi-omic data analysis
- processing, analyzing and interpreting Next-Generation Sequencing (NGC) data
- integrated analysis of genomic and other biological and medical data
- biomarker discovery
- pathway or network analysis machine learning-based modeling
- gene expression analysis
- gene-set enrichment and functional analysis
Pricing
We offer highly competitive statistical analysis pricing. Please contact omicsanalysis@ottawaheart.ca for a quote. Include all project details in your request.
Education and Training
Extensive training in genetics and bioinformatics is provided in conjunction with the Cardiovascular Research Methods Centre. Our education and training activities occur at the undergraduate, graduate, postgraduate and fellowship levels.