Population Health Research Program in Heart Failure and Cardiovascular Interventions (Team Soleil)
Team Soleil’s research program is based on heart failure and long-term outcomes after cardiovascular interventions. The scope of work encompasses precision medicine, sex and gender epidemiology, as well as patient-oriented outcomes.
Specific projects include personalized perioperative and long-term risk prediction, biomarker discovery, and population-based epidemiology studies that aim to improve the outcomes of medical and surgical patients with cardiovascular diseases, finding innovative solutions for disparities and improving access to care. This is accomplished through applying machine learning and advanced statistical techniques on integrated population- and precision-based datasets. The team also specializes in the development of digital health applications and medical devices that are directly relevant to patient care and clinical operations.
- Precision-based digital tools for triaging and capacity planning.
- Predicting catastrophic clinical events.
- Application of machine learning principles in biomarker discovery.
- Influence of sex on cardiac referral, quality indicators and outcomes in heart failure care in Ontario.
- Sex and social disparities in long-term outcomes after cardiac interventions.
- Comparative effectiveness of cardiac surgery vs. percutaneous interventions.
See at Google Scholar.
- Sun LY, Rodger J, Duffett L, Tulloch H, Crean AM, Chong AY, Rubens FD, MacPhee E, Mesana TG, Lee DS, van Diepen S, Beanlands RS, Ruel M, Julien AM, Bilodeau J. (2021). Derivation of Patient-Defined Adverse Cardiovascular and Noncardiovascular Events through a Modified Delphi Process. JAMA Network Open. 4(1): e2032095.
- Sun LY, Mielniczuk LM, Liu PP, Beanlands R, Chih S, Davies R, Coutinho T, Lee DS, Austin PC, Bader Eddeen A, Tu JV. (2020). Sex-Specific Temporal Trends in Ambulatory Heart Failure Incidence, Mortality and Hospitalization in Ontario, Canada from 1994-2013: a Population-Based Cohort Study. BMJ Open. 10(11):e044126.
- Sun LY, Bader Eddeen A, Ruel M, MacPhee E, Mesana TG. (2020). Derivation and Validation of a Clinical Model to Predict Intensive Care Unit Length of Stay after Cardiac Surgery. JAHA. Sep 29:e017847.
- Etherington E, Deng M, Boet S, Johnston A, Mansour F, Said H, Zheng K, Sun LY. (2020). The impact of physician sex/gender on processes of care, and clinical outcomes in cardiac operative care: A systematic review. BMJ Open. 10(9):e037139.
- Sun LY, Gaudino M, Chen RJ, Bader Eddeen A, Ruel M. (2020). Long-Term Outcomes of Patients with Severely Reduced Left Ventricular Ejection Fraction Undergoing Percutaneous Coronary Intervention versus Coronary Artery Bypass Grafting. JAMA Cardiology. Online first Apr 8:e200239.
- Mamas MA, Brown SA, Sun LY. (2020). Coronary Artery Disease in Cancer patients; It’s always the small pieces that make the bigger picture. Mayo Clinic Proceedings. 95(9):1819-1821.
- Ngu J, Jabagi H, Chung A, Boodhwani M, Ruel M, Bourke M, Sun LY. (2020). Defining an intraoperative hypotension threshold in association with de novo renal replacement therapy after cardiac surgery. Anesthesiology. 132(6):1447-1457.
- Sun LY, Spence S, Benton S, Beanlands R, Bader Eddeen A, Lee DS. (2020). Age, Not Sex, Modifies the
- Effect of Frailty on Long-term Outcomes after Cardiac Surgery. Annals of Surgery. Online first June 24. JIF: 9.5
- Hayatsu Y, Ruel M, Bader Eddeen A, Sun LY. (2020). Single versus Multiple Arterial Revascularization in Patients with Reduced Renal Function: Long-Term Outcome Comparisons in 23,406 CABG Patients from Ontario, Canada. Annals of Surgery. Online first June 11.
- Rubens FD, Coutinho T, Bader Eddeen A, Sun LY. (2020) The impact of a second arterial conduit on longterm post-discharge outcomes in women and men after coronary artery bypass grafting. Journal of Thoracic and Cardiovascular Surgery. S0022-5223(20)31007-2.