PET Research Radiochemistry

The mission of the UOHI PET Research Radiochemistry Laboratory is to provide the UOHI, the University of Ottawa and Greater Ottawa region with an onsite core facility that can offer a bench to bedside production/service, providing quality PET Radiopharmaceuticals for research projects in radiochemistry, targetry, animal-models and human imaging.

Our goal is to produce novel and established PET Radiopharmaceuticals for innovative research to help understand and guide novel therapies in cardiovascular, kidney, diabetes, oncology and neuroscience diseases.

Our lab offers the capability for research on basic radiochemistry to develop novel PET probes with the ultimate goal of translational work in humans to address scientific questions via PET imaging.

Services

RadiotracerApplication in CardiologyOther Potential Applications
13N-Ammonia

Myocardial blood flow

Animal and human MBF quantification

Renal perfusion
18F-NaF

Arterial calcific/plaque imaging

atherosclerosis

Bone cancer
18F-FTHA

Free fatty acid uptake

PAH patients and animal models

Other animal models such as MLIP +/+, +/-, -/- mice

Skeletal muscle anomalies

11C-HED

SNS innervations

Sleep apnea study

Heart failure

Atrial fibrillation

Evaluation of neuronal integrity (examination of tumours of the sympathetic nervous systems)
11C-Acetate

MBF

Myocardial oxygen consumption

Myocardial perfusion

Oxidative metabolism

Cardiac efficiency

Renal perfusion

Prostate cancer
Hepatocellular carcinoma (HCC)

Renal cell carcinoma (RCC)

Bladder carcinoma

Brain tumours

Multiple myeloma

MBF in kidney

11C-Rolipram

PDE4 ligand

Heart failure

 
18F-FPyKYNE-Losartan

AT1 receptor uptake

Heart failure, hypertension

Diabetes, renal diseases
18F-HFBCell regenerative therapy

Cell regenerative therapy

Direct Cell Labelling

18F-FPyKYNE-c(RGDyK)

αVβ3 Integrin Receptor

Inflammation

Inflammation
11C-methyl-Hydroxyfasudil

Rho-Kinase ligand

Inflammation, heart failure, hypertension

Diabetes
11C-Carfentanil 

Opioid Receptor ligand

Mental disorders

   
 Neurodegenerative disease
Alzheimer disease		Dementia
Radiotracer for Brain ImagingDescriptionField Applications
11C-RacloprideDopamine D2 receptor antagonist that has the potential of quantifying changes in extracellular dopamine release.
  • Parkinson’s Disease (Neurology)
  • Novelty Seeking Behaviour (Neuropsychiatry)
  • Fear Conditioning (Neuropsychiatry)
  • Drug Sensitisation (Neuropsychiatry)
     
18F-FEOBVHighly selective tracer to vesicular acetylcholine transporter (VAT) that is utilized as a biomarker of cholinergic innervation density.
  • Alzheimer’s Disease (Neurology)
  • Traumatic Brain Injury (Neurology)
  • Lewy Body Dementia (Neurology)
  • Parkinson’s Disease (Neurology)
  • Sleep Disorders (Neurology)
  • Schizophrenia (Neurology)
18F-SynVesT-1Synaptic vesicle glycoprotein 2A tracer 

User Fee Schedule

Prices in effect as of April 01, 2024.

Pre-Clinical Imaging and Human Clinical and Large Animal Imaging Research
 External User (CAD)Internal User (CAD)Pilot studies **
 Complete synthesis
NaF750650600
NH3430330300
Acetate800770670
HED1,2601,1601,100
LMI11951,5601,4601,300
Raclopride1,3401,2401,200
FEOBV1,7001,6001,500
SynVesT-12,0801,9801,980
a 18F-Aldehyde / BF3230230230
b 18F250/unit
($50 for additional unit)		230/unit
($50 for additional unit)		230
(50 for additional unit)
b 18F-Fx Fn400/unit
(100 for additional unit)		300/unit
(100 for additional unit)		300/unit
(100 for additional unit)
b 11C-MeI300
(15 min beam time. $100 for additional unit)		100/unit
(50 for additional unit)		100
(50 for additional unit)
b 11C-CO230 / unit
(15 min beam time)		30 / unit
(15 min beam time)		30 / unit
(15 min beam time)
Radiotracer Module Training$60 / hour$60 / hour$60 / hour
  • * The fee will increase by 1.5% each year
  • ** Pilot = maximum 10 doses
  • a = beaming/synthesis performed by Radiochemistry staff (Materials are not included)
  • b = beaming/synthesis performed by PI staff
  • Unit = 15 minutes beam time

List of Equipment

  • Siemens CTI Eclipse HP/RD Hybrid Cyclotron
  • GE Tracerlab MX (coincidence)
  • GE Tracerlab FX F-N
  • GE Tracerlab FX C-Pro
  • GE FASTlab
  • MediSMARTS Radiation Monitoring System
  • Von Gahlen Hot cells
  • SRI Gas Chromatography System
  • Radio-TLC Imaging Scanner
  • Agilent HPLC
  • Agilent GC
  • Multi-Channel Analyzer (MCA)
  • Laminar Flow Hoods and Biological Safety Cabinets
  • Capintec Dose Calibrators
  • Mettler Toledo Balance
  • Millipore Water Deionizer
  • Analytical and Semi-preparative HPLC Systems (Waters)
  • Rotary Evaporator
  • Perkin Elmer GC
  • Turbomax Auto Headspace Sampler

Contact

For service requests and more information please contact:

Dr. Christian Umeobika, PhD
Manager, Radiochemistry Laboratory
@email

Facility Staff Members

Dr. Christian Umeobika, PhD
Manager, Radiochemistry Laboratory
Develops, produces and analyses novel and established PET Radiopharmaceuticals and oversees lab operations.
@email

Elmi Mohamed
Radiochemistry Technologist
@email
Produce and analyze novel and established PET Radiopharmaceuticals.

Hugo Nolasco
Radiochemistry and Cyclotron Engineer
@email
Maintains and services all lab equipment.

Nadia Zaid
RSO
@email
Regulates radiation safety.

Poppy MacPhee
Business Manager
pmacphee@ottawaheart.ca
Invoicing, administration, business.

Rob Beanlands, MD
Medical Doctor
@email
Responsible of PERs administered to humans.