Research is focused on: a) accuracy, b) patient outcomes, 3) cost and cost-effectiveness and d) safety.
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The goals of the Atherogenomics Laboratory are to develop a comprehensive and integrated understanding of the genetic and molecular etiology of complex phenotypes, with a focus on coronary artery disease (CAD) and obesity.
The Behavioural Research Group focuses on three main themes: developing and implementing systematic approaches to smoking cessation in clinical practice settings; promoting exercise and physical activity in patients with heart disease; and examining the effectiveness and cost-efficiency of different...
The Bio-nanomaterials Chemistry and Engineering Laboratory (BnCE), under the direction of Emilio I. Alarcon, PhD, is located in the Research Centre of University of Ottawa Heart Institute. It is affiliated with the Biomaterials and Regenerative Research Program in the Division of Cardiac Surgery...
Research continues to play an important part of the mission of the Division of Cardiac Anesthesiology as we continually strive to improve patient care. Research focuses on predicting perioperative risk, characterization of patient outcomes and tailoring patient care towards prevention of adverse...
Our research program is very patient focused. In general we have two criteria when considering starting a new project. Firstly, is there an important clinical research question to be answered? Secondly, does our group have the necessary experience, skills, resources and collaborations to be able to...
Heart failure is the new epidemic in chronic cardiovascular disease. It will affect one in five Canadians over their lifetime. The one-year mortality of heart failure is at 34%. Our research is focused on the causes and treatment of heart failure from bench to bedside. With support from CIHR, Genome...
The goal of our research is to develop, advance and evaluate new and established imaging methods that will enable early, accurate, less invasive and cost-effective diagnosis of cardiovascular disease in order to optimize management for improved patient care and outcomes. The Molecular Function and...
The focus of our lab is to translate fundamental biological principles to the clinical setting. We are positioned within the Cardiology research program with projects addressing cardiac arrhythmias and regenerative medicine. Specific questions under investigation include the following: Can we devise...
The Cardiometabolic microRNA Laboratory studies how microRNAs alter the expression of key genes involved in the pathogenesis of atherosclerosis and other chronic inflammatory diseases, such as type II diabetes. The team also studies novel mechanisms of inflammation that promote plaque vulnerability...
The Cardiovascular Electrophysiology team is focusing on mechanistic studies of arrhythmogenic heart disease, with the hope of developing novel therapies for cardiac arrhythmias. Techniques used include somatic gene transfer, cellular electrophysiology, isolated organ and whole-animal studies, as...
Our research focuses on the role of behavioural, cognitive, psychological and social mechanisms and interventions for patients with cardiovascular disease and their partners, with the goal of improving cardiovascular health, mental health, and quality of life outcomes.
We are interested in understanding the fundamental mechanisms of cellular lipid homeostasis, trafficking and metabolism, particularly in lipid-loaded macrophage foam cells. During atherosclerosis, foam cells accumulate in the artery wall and are the precursor of heart disease. While today we have...
The Cardiovascular Research Methods Centre collaborates with Heart Institute investigators during all stages of the research process, from protocol design to drafting of a final manuscript for submission to a peer-reviewed journal: The Centre aims to: To collaborate with clinician and basic...
The main goal of the Cardiovascular Tissue Engineering Laboratory, under the direction of Erik Suuronen, PhD, is to develop tissue engineering and cell-based therapeutic approaches for the treatment of cardiac injury and disease. Despite major advances in therapy, there are still a significant...
Clinical Services staff are involved in research in a variety of ways, from identifying clinical problems amenable to research to leading studies as primary investigators. Staff are encouraged to present and publish the results of their academic and research activities at national and international...
Our research goals are to understand: The physiological importance of local DPP4 activity and substrate cleavage in the setting of diabetes and cardiovascular disease. The cellular sites of DPP4 important for regulation of glucose and lipid metabolism. How the gut adapts to food ingestion.
Our team performs human clinical research in the area of exercise science, cardiovascular rehabilitation and prevention and women’s health. Our research program focuses on: Understanding the role of exercise training in preventing and managing cardiovascular disease. Developing practical, valid...
Dr. Kim’s research program focuses on genetic and metabolic regulation of heart development, function and disease, with emphasis on obesity, diabetes and heart failure. First, we are interested in the molecular function and mechanism of Iroquois ( Irx) transcription factors in the heart, which are...
The Laboratory of Translational Genomics is focused on the genetics of coronary artery disease (CAD). Through unbiased Genome-Wide Association Studies (GWAS), the team has identified common genetic variants at over 40 loci that augment the risk of CAD ( Science, 2007, 316: 1488-1491; Nature Genetics...