Nominations et affiliations
Directeur et chercheur principal, Centre de méthodes de recherche en cardiologie
Institut de cardiologie de l’Université d’Ottawa
Professeur, École d’épidémiologie et de santé publique,
Université d’Ottawa
Professeur, Département de médecine,
Université d’Ottawa
Scientifique principal affilié,
l’Institut de recherche de L’Hôpital d’Ottawa
George Wells, Ph.D., est directeur et chercheur principal du Centre de méthodes de recherche en cardiologie, à l’Institut de cardiologie de l’Université d’Ottawa (ICUO). Il est aussi professeur à l’École d’épidémiologie, et de santé publique et au Département de médecine, de l’Université d’Ottawa. Enfin, il est scientifique principal affilié à l’Institut de recherche de l’Hôpital d’Ottawa.
Parcours
Le professeur Wells a travaillé intensément avec des organismes de recherche gouvernementaux et non gouvernementaux ainsi qu’avec des entreprises privées des secteurs de la pharmacologie et de la biotechnologie. Il a siégé au comité de direction de plusieurs programmes de recherche nationaux et internationaux, en plus de participer à des comités de contrôle externe de l’efficacité et de l’innocuité, à des comités d’examen des subventions scientifiques, à des comités de rédaction ainsi qu’à des comités consultatifs scientifiques. Il est actuellement rédacteur en chef adjoint du Journal of Clinical Epidemiologyet membre du comité de rédaction du Journal de l’Association médicale canadienne.
Le professeur Wells a reçu le Prix d’excellence en recherche de l’Université d’Ottawa en 2014 et le Prix du scientifique de renommée de la Société canadienne de recherches cliniques (SCRC) en 2007.
Le professeur Wells est l’auteur ou le coauteur de plus de 1035 articles publiés et de 1060 résumés scientifiques. Il a participé, à titre de chercheur principal ou de collaborateur, à plus de 310 projets de recherche soutenus par des subventions dépassant les 200 millions de dollars. Il a également fait de nombreuses présentations scientifiques lors de rencontres nationales et internationales. Il a enseigné à l’université au premier cycle et aux cycles supérieurs durant plus de 35 ans, et il a dirigé ou codirigé les thèses de plus de 100 étudiants de maîtrise ou de doctorat.
Intérêts cliniques et de recherche
En matière de recherche, ses champs d’intérêt portent sur les sujets suivants : conception et analyse d’essais cliniques; méthodologie statistique concernant les processus de maladie et la prestation des soins de santé; essais systématiques et méta-analyse; évaluations économiques; développement et évaluation des technologies d’aide à la décision pour les patients et les praticiens.
Publications
PUBLICATIONS RÉCENTES
- Parlow, S., Di Santo, P., Jung, R., Fam, N., Czarnecki, A., Horlick, E., Abdel-Razek, O., Chan, V., Hynes M., Nicholson, D., Dryden, A., Fernando, S., Wells, G.A., Bernick, J., Labinaz, M., Mathew, R., Simard, T., and Hibbert, B., “Transcatheter Mitral Valve Repair for Inotrope Dependent Cardiogenic Shock-Design and Rationale of the CAPITAL MINOS Trial”. American Heart Journal, (E-pub ahead of print – DOI: 10.1016/j.ahj.2022.08.008 – August 2022), Vol. 254, 81-87, December 2022.
- Andrade, J., Deyell, M., Macle, L., Wells, G.A., Bennett, M., Essebag, V., Champagne, J., Roux, J-F., Yung, D., Skanes, A., Khaykin, Y., Morillo, C., Jolly, U., Novak, P., Lockwood, E., Amit, G., Angaran, P., Sapp, J., Wardell, S., Lauck, S., Cadrin-Tourigny, J., Kochhauser, S. and Verma, A., for the EARLY-AF Investigators, “Progression of Atrial Fibrillation after Cryoablation or Drug Therapy”. New England Journal of Medicine, (DOI: 10.1056/NEJMoa2212540), November 2022.
- Alqurashi, W., Shaker, M., Wells, G.A., Collins, G., Greenhawt, M., Curran, J., Zernek, R., Schuh, S., Ellis, A., Gerdts, J., Kreviazuk, C., Dixon, A., Eltorki, M., Freedman, S., Gravel, J., Poonai, N. Worm, M. and Plint, A., “Canadian Anaphylaxis Network-Predicting Recurrence after Emergency Presentation for Allergic REaction (CAN-PREPARE): a prospective, cohort study protocol”. British Medical Journal (BMJ) (Open), (DOI: 10.1136/bmjopen-2022-061976), Vol. 12, No. 10, 1-9, October 2022.
- Reed, J., Terada, T., Vidal-Almela, S., Tulloch, H., Mistura, M., Birnie, D., Wells, G.A., Nair, G., Hans, H., Way, K., Chirico, D., O’Neill, C. and Pipe, A., “Effect of High-Intensity Interval Training in Patients with Atrial Fibrillation: A Randomized Controlled Trial”. Journal of the American Medical Association (JAMA) Network Open, (DOI: 10.1001/jamanetworkopen.2022.39380), Vol, 5, No. 10, e2239380, October 2022.
- Bery, A., Sharma, M., Nemnom, M-J., Johns, P., Lelli, D., Sivilott, M., Emond, M., Stiell, I., Stotts, G., Lee, J., Worster, A., Morris, J., Cheung, K-W., Jin, A., Oczkowski, W., Sahlas, D., Murray, H., Mackey, A., Verreault, S., Camden, M-C., Yip, S., Teal, P., Gladstone, D., Boulos, M., Chagnon, N., Shouldice, E., Atzema, C., Slaoui, T., Teitelbaum, J., Wells, G.A. and Perry, J., “Risk of Stroke is Low After Transient Ischemic Attack Presentation with Isolated Dizziness”. Canadian Journal of Emergency Medicine, (E-pub ahead of print - DOI: 10.1007/s43678-022-00391-0 – October 2022) 2022.
- Hazelwood, G., Scheir, O., Bykerk, V., Kamso, M., Tugwell, P., Wells, G.A., Richards, D., Proulx, L., Hull, P. and Bartlett, S., “Frequency of Symptomatic Adverse Events in Rheumatoid Arthritis: An Exploratory Online Survey”. Journal of Rheumatology and Clinical Highlights, (E-pub ahead of print – DOI: org/10.3899/jrheum.210688 – March 2022), Vol. 49, No. 9, 998-1005, September 2022.
- Paterson, G., Gaboury, I., Bernick, J., Wells, G.A., Tugwell, P., Toupin-April, Karin, “A pragmatic pilot randomized controlled trial of the OA Go Away, a self-management intervention for promoting adherence to physical activity among individuals with osteoarthritis of the hip or knee”. Physiotherapy Canada, (E-pub ahead of print – August 2022), Vol. 24 E20200110, 1-8, September 2022.
- Khan, F., Bai, A., Kelly, S., Skidmore, B., Dickson, C., Nunn, A., Rutledge-Taylor, K. and Wells, G.A., “Effectiveness and Safety of Antibiotic Prophylaxis for Persons Exposed to Cases of Invasive Group A Streptococcal Disease: A Systematic Review”. Open Forum Infectious Diseases, (E-pub ahead of print - DOI: org/10.1093/ofid/ofac244 - May 2022), Vol. 9, No. 8, 1-17, August 2022.
- Nair, G., Birnie, D., Wells, G.A., Nery, P., Redpath, C., Sarrazin, J-F., Roux, J-F., Parkash, R., Bernier, M., Sterns, L., Novak, P., Veenhuyzen, G., Morillo, C., Singh, S., Sturmer, M., Chauhan, V., Angaran, P. and Essebag, V., “Augmented Wide Area Circumferential Catheter Ablation for Reduction of Atrial Fibrillation Recurrence (AWARE) Trial: Design and Rationale”. (E-Pub ahead of print - DOI: org/10.1016/j.ahj.2022.02.009 – February 2022), American Heart Journal, Vol. 248, S0002-8703, 00043-6, 1-12, June 2022.
- Dewidar, O., Birnie, D., Welch, V., Tesfu Dawit, H., Barbeau, V. and Wells, G.A., “Sex Differences in Implantation and Outcomes of Cardiac Resynchronization Therapy in Real-World Settings: A Systematic Review of Cohort Studies”. Canadian Journal of Cardiology (CJC) Open, (E-Pub ahead of print - DOI: org/10.1016/j.cjco.2021.09.003 – September 2021), Vol. 4, No. 1, 75-84, January 2022.
ARTICLES PARUS DANS DES REVUES SCIENTIFIQUES
- Andrade, J., Macle, L., Bennett, M., Howkins, N., Essebag, V., Champagne, J., Roux, J-F., Makanjee, B., Tang, A., Skanes, A., Khaykin, Y., Morillo, C., Jolly, U., Lockwood, E., Amit, G., Angaran, P., Sapp, J., Wardell, S., Wells, G.A., Verma, A. and Deyell, M., "Randomized Trial of Conventional Versus Radiofrequency Needle Transseptal Puncture for Cryoballoon Ablation: The CRYO-LATS Trial". Journal of Interventional Cardiac Electrophysiology, (DOI: org/10.1007/s10840-022-01277-y), 1-9, June 2022.
- Boczar, K., Shin, S., Bezzina, K., Geejo, A., Pearson, A., Shahab, S., Fehlmann, C., Visintini, S., Beanlands, R. and Wells, G.A., “Examining Anti-Inflammatory Therapies in the Prevention of Cardiovascular Events: Protocol for a Systematic Review and Network Meta-Analysis of Randomised Controlled Trials”. British Medical Journal (BMJ) (Open), (DOI: org/10.1136/bmjopen-2022-062702), Vol. 12, No. 6, e062702, 1-6, June 2022.
- Straus, S., Hutton, B., Moher, D., Kelly, S., Wells, G.A. and Tricco, A., “Providing Valid Evidence for Decision-Making: the Drug Safety and Effectiveness Network Methods and Applications Group in Indirect Comparisons (DSEN MAGIC)”. FACETS, (DOI: ORG/110.1139/FAETS-2021-0141), Vol. 7, 809-821, May 2022.
- Abdulaziz, K., Perry, J., Yadav, K., Dowlatshahi, D., Stiell, I., Wells, G.A. and Taljaard, M., “Quality and Transparency of Reporting Derivation and Validation Prognostic Studies of Recurrent Stroke in Patients with TIA and Minor Stroke: A Systematic Review”. Diagnostic and Prognostic Research, (DOI: org/110.1186/s41512-022-00123-z), Vol. 6, No. 9, 1-13, May 2022.
- Way, K., Birnie, D., Blanchard, C., Wells, G.A., Dorian, P., Jorstad, H., Daha, I., Suskin, N., Oh, P., Parkash, R., Poirier, P., Prince, S., Tulloch, H., Pipe, A., Hans, H., Wilson, J., Comeau, K., Vidal-Almela, S., Terada, T. and Reed, J., “The Physical Activity Levels and Sitting Time of Adults Living with Atrial Fibrillation: The CHAMPLAIN-AF Study”. Canadian Journal of Cardiology, (E-pub ahead of print – DOI: org/10.1016/j.cjco.2022.01.004 – January 2022), Vol. 4, No. 5, 449-465, May 2022.
- Goh, C., Parlow, S., Di Santo, P., Simard, T., Jung, R., Ahmed, Z., Verreault-Julien, L., Kuhar, P., Chan, V., Al-Atassi, T., Toeg, H., Bernick, J., Wells, G.A., Ruel, M. and Hibbert, B., “Utility of a Smartphone Application in Assessing Palmar Circulation Prior to Radial Artery Harvesting for Coronary Artery Bypass Grafting: Rationale and Design of the Randomized CAPITAL iRADIAL-CABG TRIAL”. British Medical Journal (BMJ), (E-pub ahead of print – DOI: org/10.1136/bmjopen-2021-055580 – March 2022), Vol. 12, No. 4, e055580, April 2022.
- Yousef (Abdelrazeq), S., Colman, I., Papadimitropoulos, M., Manuel, D., Hossain, A., Faris, M. and Wells, G.A., “Vitamin D and Chronic Diseases among First-Generation Immigrants: A Large-Scale Study using Canadian Health Measures Survey (CHMS) Data”. Nutrients, (E-pub ahead of print – DOI: org/10.3390/nul4091760 – April 2022), Vol. 14, No. 9, 1760, 1-18, May 2022.[CR1]
- P., Pi, L., Aldawood, W., Sadek, M., Redpath, C., Birnie, D., Alqarawi, W., Zagzoog, A., Golian, M., Klein, A., Ramirez, D., Green, M., Chen, L., Visintini, S., Wells, G.A. and Nair, G., “Rhythm Monitoring Strategy and Arrhythmia Recurrence in Atrial Fibrillation Ablation Trials: A Systematic Review”. Canadian Journal of Cardiology (Open), (E-pub ahead of print - DOI: org/10.1016/j.cjco.2022.02.001 – February 2022), Vol. 4, No. 5, 488-496, May 2022.
- Santi, N., Wu, K., Redpath, C., Nery, P., Huang, W., Burwash, I., Bernick, J., Wells, G.A., McArdle, B., Chow, B., Birnie, D., Garrard, L., deKemp, R. and Beanlands, R., “Metabolic Activity of the Left and Right Atria are Differentially Altered in Patients with Atrial Fibrillation and LV Dysfunction”. Journal of Nuclear Cardiology, (E-pub ahead of print – DOI: 10.1007/s12350-021-02878-2 – January 2022), 2022.
- Rooprai, J., Boodhwani, M., Beauchesne, L., Chan, K-L., Dennie, C., Wells, G.A. and Coutinho, T., “Central Hypertension in Patients with Thoracic Aortic Aneurysms: Prevalence and Association with Aneurysm Size and Growth”. American Journal of Hypertension, (DOI: org/10.1093/ajh/hpaa183), Vol. 35, No. 1, 79-86, January 2022.
- Kelly, S., Greene-Finestone, L., Yetley, E., Benkhedda, K., Brooks, S., Wells, G.A. and MacFarlane, A., “NUQUEST – NUtrition QUality Evaluation Strenghthening Tool: Development of Tools for Evaluation of Risk of Bias in Nutrition Studies”. The American Journal of Clinical Nutrition, (DOI: org/10.1093/ajcn/nqab335), Vol. 115, No. 1, 256-271, January 2022.
- Tomlinson, E., Pardo Pardo, J., Dodd, S., Sivesind, T., Szeto, M., Dellavalle, R., Skoetz, N., Laughter, M., Wells, G.A. and Tugwell, P., “Substantial Heterogeneity found in Reporting Mortality in Cochrane Systematic Reviews and Core Outcome Sets in COMET Database”. Journal of Clinical Epidemiology, (E-pub ahead of print – DOI: 10.1016/j.jclinepi.2022.01.006 – January 2022), Vol. 145, 47-54, May 2022.
- Boczar, K., Beanlands, R., Wells, G. A. and Coyle, D., “Cost-Effectiveness of Canakinumab from a Canadian Perspective for Recurrent Cardiovascular Events”. Canadian Journal of Cardiology, (E-pub ahead of print – DOI: org/10.1016/j.cjco.2022.01.003 – January 2022), Vol 4, No. 5, 441-448, May 2022.