Dr. Darryl Davis is Clinician-Scientist and Cardiac Electrophysiologist in the Division of Cardiology at the University of Ottawa Heart Institute. He directs the Cardiac Translational Research Laboratory. He is an Associate Professor in the Faculty of Medicine at the University of Ottawa and is cross-appointed as an adjunct professor within the Department of Cellular and Molecular Medicine at the University of Ottawa.
Background
Dr. Davis earned his BSc in Biology and Pharmacology from McMaster University in Hamilton, Ontario. He completed medical school and residency training in Internal Medicine, Cardiology and Cardiac Electrophysiology at the University of Ottawa. The desire to understand, engage and expand novel cardiac therapies at a fundamental level prompted Dr. Davis to continue his postgraduate training in the laboratory of Dr. Eduardo Marbán. There, he developed novel techniques to culture resident cardiac stem cells from routine myocardial biopsies with an emphasis on developing novel means of engineering stem cells to enhance potency, engraftment and retention.
Research and clinical interests
Dr. Davis is exploring novel strategies to enhance the regenerative capacity and retention of cardiac stem cells. These cell and gene therapies will combine discovery and validation work in animal models with the ultimate goal of translation into clinical practice.
Publications
See current publications list at PubMed
Selected Publications:
- Tilokee EL, Latham N, Jackson R, Mayfield AE, Ye B, Mount S, Lam BK, Suuronen EJ, Ruel M, Stewart DJ, Davis DR. Paracrine Engineering of Human Explant-Derived Cardiac Stem Cells to Over-Express Stromal-Cell Derived Factor 1? Enhances Myocardial Repair.Stem Cells. 2016 Apr 5. doi: 10.1002/stem.2373. [Epub ahead of print]
- Jackson R, Tilokee EL, Latham N, Mount S, Rafatian G, Strydhorst J, Ye B, Boodhwani M, Chan V, Ruel M, Ruddy TD, Suuronen EJ, Stewart DJ, Davis DR. Paracrine Engineering of Human Cardiac Stem Cells With Insulin-Like Growth Factor 1 Enhances Myocardial Repair. J Am Heart Assoc. 2015 Sep 11;4(9):e002104. doi: 10.1161/JAHA.115.002104.
- Molgat AS, Tilokee EL, Rafatian G, Vulesevic B, Ruel M, Milne R, Suuronen EJ, Davis DR. Hyperglycemia inhibits cardiac stem cell-mediated cardiac repair and angiogenic capacity. Circulation. 2014 Sep 9;130(11 Suppl 1):S70-6.
- Mayfield AE, Tilokee EL, Davis DR. Resident cardiac stem cells and their role in stem cell therapies for myocardial repair. Can J Cardiol. 2014 Nov;30(11):1288-98. doi: 10.1016/j.cjca.2014.03.018. Epub 2014 Mar 20. Review.
- Mayfield AE, Tilokee EL, Latham N, McNeill B, Lam BK, Ruel M, Suuronen EJ, Courtman DW, Stewart DJ, Davis DR. The effect of encapsulation of cardiac stem cells within matrix-enriched hydrogel capsules on cell survival, post-ischemic cell retention and cardiac function. Biomaterials. 2014 Jan;35(1):133-42. doi: 10.1016/j.biomaterials.2013.09.085. Epub 2013 Oct 4.
- Latham N, Ye B, Jackson R, Lam BK, Kuraitis D, Ruel M, Suuronen EJ, Stewart DJ, Davis DR. Human blood and cardiac stem cells synergize to enhance cardiac repair when cotransplanted into ischemic myocardium. Circulation. 2013 Sep 10;128(11 Suppl 1):S105-12. doi: 10.1161/CIRCULATIONAHA.112.000374.
- Tilokee EL, Davis DR. Circulating progenitor cells as a heart failure biomarker: does a failing marrow predict a failing heart? Can J Cardiol. 2013 Jun;29(6):662-3. doi: 10.1016/j.cjca.2012.09.011. Epub 2013 Jan 9.
- Davis DR, Ruckdeschel Smith R, Marbán E. Human cardiospheres are a source of stem cells with cardiomyogenic potential. Stem Cells. 2010 May;28(5):903-4. doi: 10.1002/stem.413.
- Davis DR, Kizana E, Terrovitis J, Barth AS, Zhang Y, Smith RR, Miake J, Marbán E. Isolation and expansion of functionally-competent cardiac progenitor cells directly from heart biopsies. J Mol Cell Cardiol. 2010 Aug;49(2):312-21. doi: 10.1016/j.yjmcc.2010.02.019. Epub 2010 Mar 4.
- Davis DR, Zhang Y, Smith RR, Cheng K, Terrovitis J, Malliaras K, Li TS, White A, Makkar R, Marbán E. Validation of the cardiosphere method to culture cardiac progenitor cells from myocardial tissue. PLoS One. 2009 Sep 25;4(9):e7195. doi: 10.1371/journal.pone.0007195.